TABLE 2.

Effects of topical treatment given with various schedules of administration on the development of herpetic cutaneous lesions in infected mice

Schedulea	Treatmentb	AUCc	P (compared to the following group)d:
			a	b	c	d	e
tid for 4 days starting 24 h postinfection	None	33.78 ± 3.89		NS	<0.01	<0.01	<0.01
	Gel alone	35.23 ± 4.21	NS		<0.01	<0.01	<0.01
	Gel with 5% ACV	11.60 ± 2.03	<0.01	<0.01		NS	NS
	Acyclovir ointment	10.60 ± 0.28	<0.01	<0.01	NS		NS
	Gel with 3% PFA	15.30 ± 2.88	<0.01	<0.01	NS	NS
qd for 1 day starting 24 h postinfection	None	38.12 ± 4.81			<0.01	NS	NS
	Gel with 5% ACV	20.81 ± 3.97	<0.01			<0.05	NS
	Acyclovir ointment	32.15 ± 5.71	NS		<0.05		NS
	Gel with 3% PFA	34.75 ± 8.08	NS		NS	NS
tid for 4 days starting 5 days postinfection	None	54.00 ± 2.21		NS	<0.01	NS	NS
	Gel alone	27.71 ± 8.28	NS		<0.05	NS	NS
	Gel with 5% ACV	17.08 ± 4.33	<0.01	<0.05		<0.05	NS
	Acyclovir ointment	36.17 ± 8.08	NS	NS	<0.05		NS
	Gel with 3% PFA	34.20 ± 8.11	NS	NS	NS	NS

^atid, three times daily; qd, once daily. 

^bACV, acyclovir; PFA, foscarnet. 

^cValues are means ± standard errors of the means, calculated as [(score on day 4 + score on day 10)/2] + sum of all scores between day 4 and day 10. 

^dNS, not significant (i.e., P > 0.05). a, infected untreated mice; b, infected mice treated with the gel alone; c, infected mice treated with the gel containing 5% ACV; d, infected mice treated with the acyclovir ointment; e, infected mice treated with the gel containing 3% PFA.