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. 2022 Feb 8;10(2):400. doi: 10.3390/biomedicines10020400

Figure 1.

Figure 1

Model of human NK cell development. NK development from HSCs is regulated by multiple cytokines (e.g., FLT3-L, c-Kit ligand, IL-3, IL-7, and IL-15). Modifications of the molecules’ expression patterns are correlated with developmental stages. Abbreviations—Flt3l: FMS-like tyrosine kinase 3 ligand; c-Kit: c-Kit ligand; IL: interleukin; HSC: hematopoietic stem cell; MLP: compromised multipotent lymphoid progenitor; CLP: common lymphoid progenitor; NKP: NK cell lineage precursor; iNK: immature NK cell; mNK: mature NK cell.