Table 2.
Distribution of genotype frequencies in cases and controls in a large data set (255 samples). LM: all cases with leiomyomata. FP: cases with a familial predisposition. p-value less than 0.05 is shown in bold.
| Gene | SNP ID | Genotype/Allele | Total | UL Patients without FP | UL Patients with FP | Control |
p-Value Controls vs. All LM/ Controls vs. FP |
OR (95%CI) All LM/FP |
|---|---|---|---|---|---|---|---|---|
| CELF4 | rs2861221 | CC/CG/GG | 0.70/0.25/0.05 | 0.65/0.32/0.03 | 0.79/0.19/0.02 | 0.60/0.30/0.10 | 0.087/0.017 | 1.33/2.33 |
| rs12457644 | GG/AG/AA | 0.69/0.22/0.09 | 0.64/0.27/0.08 | 0.79/0.17/0.04 | 0.53/0.33/0.13 | 0.045/0.013 | 2.21/3.64 | |
| FBN2 | rs11742635 | GG/GT/TT | 0.73/0.24/0.03 | 0.74/0.24/0.02 | 0.77/0.22/0.01 | 0.57/0.37/0.07 | 0.137/0.025 | 1.99/3.33 |
| rs17677069 | AA/AG/GG | 0.69/0.25/0.05 | 0.60/0.40/0 | 0.79/0.17/0.04 | 0.53/0.30/0.17 | 0.007/0.001 | 2.6/3.95 | |
| KCNMB2 | rs12637801 | CC/CA/AA | 0.75/0.23/0.02 | 0.76/0.22/0.02 | 0.79/0.18/0.03 | 0.53/0.47/0 | 0.006/0.010 | 4.4/3.95 |
| ESR1 | rs3020434 | CC/CT/TT | 0.62/0.33/0.05 | 0.59/0.27/0.08 | 0.71/0.27/0.03 | 0.43/0.50/0.07 | 0.020/0.005 | 2.84/4.09 |