Table 1.
Information about the four posttraumatic stress disorder (PTSD) and four major depressive disorder (MDD) genome-wide association study (GWAS) summary statistics, including the original publication, characteristics of the sample, number (N) of cases and controls in original GWAS, liability scale SNP-based heritability (h2SNP) and standard error (s.e.) from High Definition Likelihood
| Phenotype | Paper containing original GWAS | Sample characteristics | N cases | N controls | h2SNP (liability scale) | s.e. |
|---|---|---|---|---|---|---|
| UK Biobank PTSD | Nievergelt et al. (2019) | Probable PTSD phenotype was defined in UK Biobank participants based on self-report answers to PTSD Checklist (PCL) 6 (Civilian version) in the Mental Health Questionnaire | 10 389 | 115 799 | 0.20 | 0.009 |
| Psychiatric Genomics Consortium 1.5 PTSD | Nievergelt et al. (2019) | Sample comprises 59 studies of PTSD. Most cases were clinically ascertained through telephone or face-to-face interviews | 12 823 | 35 648 | 0.06 | 0.011 |
| Million Veteran Program PTSD | Stein et al. (2021) | Sample comprises US veterans. PTSD was algorithmically defined based on electronic health records Confirmed war- and combat exposure: 27.5% No exposure: 29.3% Unknown exposure: 43.1% |
36 301 | 178 107 | 0.06 | 0.015 |
| MDD with reported trauma | Coleman et al. (2020) | Phenotype was defined in UK Biobank participants. Sample comprises cases who met criteria for MDD and controls who did not meet criteria for MDD based on answers to the Composite International Diagnostic Interview Short Form (CIDI-SF). Cases and controls reported at least two traumatic life events (Table 3) in the Mental Health Questionnaire | 13 393 | 10 701 | 0.24 | 0.017 |
| MDD without reported trauma | Coleman et al. (2020) | Phenotype was defined in UK Biobank participants. Sample comprises cases who met criteria for MDD and controls who did not meet criteria for MDD based on answers to the Composite International Diagnostic Interview Short Form (CIDI-SF). Cases and controls reported no traumatic life events (Table 3) in the Mental Health Questionnaire | 9487 | 39 677 | 0.15 | 0.020 |
| Recurrent MDD | Coleman et al. (2019) | Phenotype was defined in UK Biobank participants. Cases met criteria for MDD based on answers to the Composite International Diagnostic Interview Short Form (CIDI-SF) and reported more than one depressive episode in the Mental Health Questionnaire. Controls did not meet criteria for MDD | 17 451 | 63 482 | 0.22 | 0.009 |
| Single-episode MDD | Coleman et al. (2019) | Phenotype was defined in UK Biobank participants. Cases met criteria for MDD based on answers to the Composite International Diagnostic Interview Short Form (CIDI-SF) and reported one depressive episode in the Mental Health Questionnaire. Controls did not meet criteria for MDD | 12 024 | 63 482 | 0.10 | 0.008 |
Further details of the phenotypes and how observed scale h2SNP estimates were converted to the liability scale are presented in online Supplementary Material