Table 4.

High Definition Likelihood (HDL) genetic correlation estimates (r_g), standard errors (s.e.) and 95% confidence intervals (lower and upper CI) of (1) UK Biobank posttraumatic stress disorder (UKB-PTSD), (2) Psychiatric Genomics Consortium 1.5 PTSD (PGC1.5-PTSD) and (3) Million Veteran Program PTSD (MVP-PTSD) with the four major depressive disorder (MDD) categories

PTSD phenotype	MDD phenotype	rg	s.e.	Lower CI	Upper CI	p (diff 0)	p (diff 1)
UKB-PTSD	MDD with reported trauma	0.6040	0.0550	0.4962	0.7118	4.92 × 10−28	6.02 × 10−13
UKB-PTSD	MDD without reported trauma	0.4701	0.0742	0.3247	0.6155	2.43 × 10−10	9.23 × 10−13
UKB-PTSD	Recurrent MDD	0.7134	0.0481	0.6191	0.8077	1.03 × 10−49	2.55 × 10−9
UKB-PTSD	Single-episode MDD	0.6466	0.0691	0.5112	0.7820	8.35 × 10−21	3.15 × 10−7
PGC1.5-PTSD	MDD with reported trauma	0.5520	0.0746	0.4058	0.6982	1.35 × 10−13	1.91 × 10−9
PGC1.5-PTSD	MDD without reported trauma	0.4841	0.1107	0.2671	0.7011	1.22 × 10−5	3.16 × 10−6
PGC1.5-PTSD	Recurrent MDD	0.6937	0.0821	0.5328	0.8546	2.94 × 10−17	1.91 × 10−4
PGC1.5-PTSD	Single-episode MDD	0.7560	0.1403	0.4810	1.0310	7.09 × 10−8	0.08
MVP-PTSD	MDD with reported trauma	0.5397	0.0938	0.3559	0.7235	8.77 × 10−9	9.24 × 10−7
MVP-PTSD	MDD without reported trauma	0.4859	0.0871	0.3152	0.6566	2.41 × 10−8	3.58 × 10−9
MVP-PTSD	Recurrent MDD	0.5600	0.0532	0.4557	0.6643	6.57 × 10−26	1.33 × 10−16
MVP-PTSD	Single-episode MDD	0.6291	0.1113	0.4110	0.8472	1.59 × 10−8	8.61 × 10−4

p (diff 0) refers to p value to test whether the r_g differs from 0. p (diff 1) refers to p value to test whether the r_g differs from 1. Genetic correlations were considered significant if they surpassed the Bonferroni-adjusted α (p < 0.0125). Significant p values are shown in bold.