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. 2022 Mar 26;22:334. doi: 10.1186/s12885-022-09428-0

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — SubB2M-_A12-SPR analysis of cancer-free and Stage I – IV breast cancer serum samples. A 22 serum samples from cancer-free females, 24 Stage I, 24 Stage II, 24 Stage III and 24 Stage IV serum samples were analyzed by SubB2M-_A12-SPR assay. The mean GPUs from duplicate analyses for each serum sample are shown. Error bars = ± 1 SD from the mean for each group. Statistical analysis was performed using two-tailed unpaired t-tests. **** = P-value < 0.0001 compared to Normal. Duplicate, independent assays were performed with both showing the same trends. One representative assay is shown. Only values above 0 are shown. B Cancer-free controls compared to early stage breast cancer samples only (Stage I and II samples only from Fig. 3A). C Descriptive statistics of data from breast cancer patient serum samples and cancer-free controls