Table 3.

Risk factors for occurrence of IFD

Variables	IFD (n = 22)	Univariate analysis		Multivariate analysis
		χ2	P value	P value	HR (95%CI)
Recipient age			0.086	0.130	1.067 (1.014–1.122)
Recipient sex		0.604	0.437
Male	14 (63.6%)
Female	8 (36.4%)
Underling disease		0.606	0.962
AA	2 (9.1%)
ALL	7 (31.8%)
AML	10 (45.5%)
MDS	2 (9.1%)
Others	1 (4.5%)
Donor age			0.6828
> 36	13 (54.2%)
≤ 36	11 (45.8%)
Donor sex		0.491	0.483
Male	18 (81.8%)
Female	4 (18.2%)
Blood type		1.747	0.417
Match	11 (50.0%)
Major mismatch	7 (31.8%)
Minor mismatch	4 (18.2%)
Neutrophil enengraftment	21 (95.5%)	2.292	0.130
Platelet engraftment	19 (86.4%)	2.131	0.144
aGVHD	21 (95.4%)
I–II	16 (72.7%)	8.875	0.012	0.181	17.896 (2.145–49.361)
III–IV	5 (22.7%)	10.422	0.005	0.017	13.987 (1.132–62.999)
cGVHD	3 (13.6%)	1.686	0.430
CMV	20 (90.9%)	6.962	0.008	0.007	35.97 (2.630–492.01)
Epstein–Barr virus	5 (22.7%)	1.128	0.298
Recipient rs1554013		3.030	0.082	0.614	0.352 (0.078–1.589)
Recipient rs2243283		4.659	0.031	0.066	3.303 (0.924–11.809)
Recipient rs419598		3.080	0.079	0.088	4.133 (0.630–27.104)
Recipient rs4804800		3.522	0.061	0.073	5.898 (0.847–41.068)
Recipient rs2305619		4.520	0.034	0.006	10.249 (1.982–53.004)
Recipient rs7248637		4.159	0.041	0.749	1.933 (0.010–366.116)
Donor rs7309123		4.349	0.037	0.069	1.066 (0.256–4.449)
Donor rs419598		7.934	0.005	0.084	3.545 (0.900–13.965)
Donor rs3921		5.830	0.016	0.995	3.646 (0–1467)
Donor rs4257674		5.238	0.022	0.965	0.045 (0–1806)
Donor rs2305619		2.719	0.099	0.046	1.384 (0.351–5.466)

AML acute myeloid leukemia, ALL acute lympphocytic leukemia, AA aplastic anemia, MDS myelodysplastic syndrome, HLA human leukocyte antigen, aGVHD acute graft-versus-host disease, cGVHD chronic graft-versus-host disease, CMV cytomegalovirus