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. 2022 Mar 11;4:785698. doi: 10.3389/fgeed.2022.785698

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Copyright © 2022 Lisjak, De Caneva, Marais, Barbon, Biferi, Porro, Barzel, Zentilin, Kay, Mingozzi and Muro.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Chimeric Alb-hFIX mRNA expression levels in mice treated at P2 and P60 and evaluation of anti-hFIX neutralizing antibodies. (A) Analysis of hybrid Alb-hFIX mRNA expression levels. Alb-hFIX mRNA expression was evaluated in both treated groups (P2, n = 10, and P60, n = 8) and endogenous mFIX mRNA was analyzed in wild-type mice. The fold-increase between hFIX in treated mice and endogenous mFIX in WT mice is indicated; (B) Anti-hFIX neutralizing antibodies were measured using an ELISA assay. Mice plasma was analyzed at different time-points by incubation with hFIX recombinant protein. An anti-hFIX antibody was used as a positive control.