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IL-6 promoter methylation level in patients with HBV-associated HCC, CHB and HCs. The IL-6 methylation level was significantly lower in patients with HBV-associated HCC than in those with CHB (p < 0.001) but higher than that in HCs (p = 0.026). Meanwhile, methylation levels of the IL-6 promoter were significantly higher in CHB patients than in healthy controls (P < 0.001) ***p < 0.001, *p < 0.05.
