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. 2022 Mar 11;13:825834. doi: 10.3389/fimmu.2022.825834

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Copyright © 2022 Amantea, La Russa, Frisina, Giordano, Di Santo, Panno, Pignataro and Bagetta

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Ischemic PC attenuates the systemic inflammatory status caused by severe ischemia. (A) Circulating Ly-6G+ neutrophils, (B) Ly-6C+ monocytes and (C) plasma miR-329-5p levels in mice subjected to SHAM surgery, 1h MCAo preceded by sham surgery (MCAo) or by ischemic PC (15min MCAo) 72h before (PC+MCAo). *P = 0.0463 vs SHAM and P = 0.0412 vs PC+MCAo, **P = 0.0049 vs sham and P = 0.0080 vs PC+MCAo, ***P = 0.000003 vs SHAM and P = 0.00004 vs PC+MCAo (one-way ANOVA followed by Tukey’s post-hoc test, n=6-10 mice per experimental group).