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. 2022 Mar 11;13:825834. doi: 10.3389/fimmu.2022.825834

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Copyright © 2022 Amantea, La Russa, Frisina, Giordano, Di Santo, Panno, Pignataro and Bagetta

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Ischemic PC prevents elevation of IL-1β mRNA levels, while not affecting elevation of IL-10 mRNA levels caused by 1h MCAo in the ipsilateral cortex of mice. Quantitative PCR was used to quantify mRNA levels of (A) IL-1β and (B) IL-10 in the ipsilateral cortex of mice subjected to SHAM surgery, ischemic PC (15 min MCAo followed by 72h of reperfusion), 1h MCAo followed by 24h of reperfusion (MCAo) or PC+MCAo. Data were analysed by one-way ANOVA followed by Tukey’s post-hoc test (^§P = 0.0001 vs SHAM and P = 0.0001 vs PC and P = 0.0063 vs MCAo; *P = 0.0173 vs SHAM and P = 0.0290 vs PC; ^#P = 0.0401 vs SHAM; n = 6-7 mice per experimental group).