TABLE 1.
Antifungal spectrum of FK463a
| Organism | MIC (μg/ml)
|
|||
|---|---|---|---|---|
| FK463 | AMPH-B | ITCZ | FLCZ | |
| Candida albicans ATCC90028 | 0.0156 | 0.5 | 0.0313 | 0.5 |
| Candida tropicalis TIMM0313 | 0.0313 | 0.5 | 0.125 | 4 |
| Candida glabrata ATCC90030 | 0.0156 | 0.5 | 1 | 16 |
| Candida kefyr ATCC28838b | 0.125 | 0.5 | 0.0625 | 0.5 |
| Candida krusei ATCC6258 | 0.125 | 1 | 0.25 | 32 |
| Candida guilliermondii ATCC9390 | 0.125 | 0.5 | 0.25 | 4 |
| Candida parapsilosis ATCC22019 | 2 | 0.5 | 0.25 | 2 |
| Candida stellatoidea IFM5491 | 0.0313 | 0.0625 | 0.0078 | 0.125 |
| Saccharomyces cerevisiae ATCC9763 | 0.125 | 0.5 | 0.25 | 2 |
| Cryptococcus neoformans TIMM0354b | >64 | 0.25 | 0.0313 | 0.5 |
| Trichosporon cutaneum IFM40104 | >64 | 2 | 0.5 | 8 |
| Trichosporon asahii TIMM3144 | >64 | 0.25 | 0.25 | 2 |
| Aspergillus fumigatus TIMM0063b | 0.0078 | 0.5 | 0.5 | >64 |
| Aspergillus niger ATCC6275b | 0.0078 | 0.25 | 0.5 | >64 |
| Aspergillus nidulans IFM5369b | 0.0078 | 1 | 0.0625 | 32 |
| Aspergillus flavus ATCC9643b | 0.0156 | 1 | 0.25 | 64 |
| Aspergillus terreus IFM40852b | 0.0156 | 1 | 0.125 | >64 |
| Aspergillus versicolor IFM41406b | 0.0156 | 0.5 | 0.0625 | 32 |
| Fusarium solani IFM41532c | >64 | 0.25 | >8 | >64 |
a
MICs were determined by the microdilution method described in National Committee for Clinical Laboratory Standards document M27-A (12). The methods used to determine the MICs for the yeasts or the molds are described in the text. Unless otherwise noted, incubation was for 48 h at 35°C.
b
Incubation was for 72 h at 35°C.
c
Incubation was for 72 h at 30°C.