TABLE 2.
MICs of FK463 for clinical isolates of yeastsa
| Organism (no. of isolates) | Compound | MIC (μg/ml)
|
||
|---|---|---|---|---|
| Range | 50% | 90% | ||
| Candida albicans (37) | FK463 | ≤0.0039–0.0156 | 0.0078 | 0.0156 |
| FLCZ | 0.125–4 | 0.25 | 0.5 | |
| ITCZ | 0.0156–0.25 | 0.0313 | 0.0313 | |
| AMPH-B | 0.25–1 | 0.25 | 0.5 | |
| Candida albicans, FLCZ resistant (4) | FK463 | 0.0156–0.0313 | 0.0156 | 0.0313 |
| FLCZ | 16–>64 | 32 | >64 | |
| ITCZ | 0.5–>8 | 0.5 | >8 | |
| AMPH-B | 0.25–0.5 | 0.5 | 0.5 | |
| Candida tropicalis (20) | FK463 | 0.0156–0.0313 | 0.0313 | 0.0313 |
| FLCZ | 0.25–>64 | 0.5 | 8 | |
| ITCZ | 0.0156–>8 | 0.125 | 0.5 | |
| AMPH-B | 0.0313–0.25 | 0.125 | 0.125 | |
| Candida glabrata (20) | FK463 | 0.0078–0.0156 | 0.0156 | 0.0156 |
| FLCZ | 4–>64 | 4 | 64 | |
| ITCZ | 0.5–>8 | 0.5 | 8 | |
| AMPH-B | 0.0625–1 | 0.5 | 1 | |
| Candida krusei (11) | FK463 | 0.125–0.25 | 0.125 | 0.125 |
| FLCZ | 16–64 | 32 | 64 | |
| ITCZ | 0.25–1 | 0.5 | 1 | |
| AMPH-B | 0.5–1 | 1 | 1 | |
| Candida parapsilosis (17) | FK463 | 0.5–2 | 1 | 1 |
| FLCZ | 0.125–4 | 0.5 | 1 | |
| ITCZ | 0.0313–0.5 | 0.125 | 0.5 | |
| AMPH-B | 0.125–0.5 | 0.25 | 0.5 | |
| Candida guilliermondii (12) | FK463 | 0.25–2 | 0.5 | 2 |
| FLCZ | 2–16 | 2 | 4 | |
| ITCZ | 0.25–4 | 0.5 | 1 | |
| AMPH-B | 0.0625–0.5 | 0.0625 | 0.25 | |
| Cryptococcus neoformansb (5) | FK463 | >64 | >64 | >64 |
| FLCZ | 1–8 | 4 | 8 | |
| ITCZ | 0.0313–0.5 | 0.25 | 0.5 | |
| AMPH-B | 0.25–0.5 | 0.25 | 0.5 | |
| Trichosporon cutaneumb (5) | FK463 | >64 | >64 | >64 |
| FLCZ | 2–16 | 8 | 16 | |
| ITCZ | 0.5 | 0.5 | 0.5 | |
| AMPH-B | 0.5–32 | 1 | 32 | |
a
MICs were determined by the microdilution method described in National Committee for Clinical Laboratory Standards document M27-A (12). The methods used to determine the MICs for the yeasts are described in the text. Unless otherwise noted, incubation was for 24 to 48 h at 35°C.
b
Incubation was for 72 h at 35°C.