TABLE 3.
MICs of FK463 for clinical isolates of Aspergillus speciesa
| Organism (no. of isolates) | Compound | MIC (μg/ml)
|
||
|---|---|---|---|---|
| Range | 50% | 90% | ||
| Aspergillus fumigatus (29) | FK463 | 0.0078–0.0313 | 0.0078 | 0.0156 |
| FLCZ | 8–>64 | >64 | >64 | |
| ITCZ | 0.0156–1 | 0.5 | 0.5 | |
| AMPH-B | 0.125–1 | 0.5 | 1 | |
| Aspergillus niger (15) | FK463 | ≤0.0039–0.0156 | 0.0078 | 0.0078 |
| FLCZ | 64–>64 | >64 | >64 | |
| ITCZ | 0.5–1 | 0.5 | 1 | |
| AMPH-B | 0.5 | 0.5 | 0.5 | |
| Aspergillus flavus (13) | FK463 | 0.0078–0.0156 | 0.0078 | 0.0156 |
| FLCZ | 8–>64 | >64 | >64 | |
| ITCZ | 0.125–0.5 | 0.5 | 0.5 | |
| AMPH-B | 0.5–1 | 1 | 1 | |
| Aspergillus terreus (7) | FK463 | ≤0.0039–0.0078 | ≤0.0039 | 0.0078 |
| FLCZ | 4–>64 | 32 | >64 | |
| ITCZ | 0.0313–0.125 | 0.125 | 0.125 | |
| AMPH-B | 0.0625–0.5 | 0.5 | 0.5 | |
a
MICs were determined by the microdilution method described in National Committee for Clinical Laboratory Standards document M27-A. The methods used to determine the MICs for Aspergillus species are described in the text. Incubation was for 72 h at 35°C.