TABLE 4.
MFCs of FK463 for clinical isolates of Candida species and A. fumigatus
| Organism (no. of isolates) | Compound | MFC (μg/ml)a
|
||
|---|---|---|---|---|
| Range | 50% | 90% | ||
| Candida albicans (12) | FK463 | 0.0156–4 | 0.0313 | 0.25 |
| FLCZ | >64 | >64 | >64 | |
| ITCZ | >8 | >8 | >8 | |
| AMPH-B | 0.5–1 | 0.5 | 1 | |
| Candida albicans, FLCZ resistant (4) | FK463 | 0.0156–0.5 | 0.0313 | 0.5 |
| FLCZ | >64 | >64 | >64 | |
| ITCZ | >8 | >8 | >8 | |
| AMPH-B | 0.5–2 | 0.5 | 2 | |
| Candida tropicalis (12) | FK463 | 0.0313–>64 | 0.0625 | >64 |
| FLCZ | 0.25–>64 | >64 | >64 | |
| ITCZ | 0.0625–>8 | >8 | >8 | |
| AMPH-B | 0.25–2 | 1 | 2 | |
| Candida glabrata (15) | FK463 | 0.0156–0.0313 | 0.0156 | 0.0313 |
| FLCZ | 4–>64 | >64 | >64 | |
| ITCZ | 0.5–>8 | >8 | >8 | |
| AMPH-B | 1–2 | 1 | 2 | |
| Candida krusei (10) | FK463 | 0.125–0.25 | 0.125 | 0.25 |
| FLCZ | 64–>64 | >64 | >64 | |
| ITCZ | 1–8 | 1 | 8 | |
| AMPH-B | 1–2 | 1 | 2 | |
| Candida parapsilosis (10) | FK463 | 2–16 | 4 | 8 |
| FLCZ | 16–>64 | >64 | >64 | |
| ITCZ | 0.5–>8 | 8 | >8 | |
| AMPH-B | 1–4 | 2 | 2 | |
| Candida guilliermondii (10) | FK463 | 1–>64 | 8 | >64 |
| FLCZ | >64 | >64 | >64 | |
| ITCZ | >8 | >8 | >8 | |
| AMPH-B | 0.5–2 | 1 | 1 | |
| Aspergillus fumigatus (19) | FK463 | >64 | >64 | >64 |
| FLCZ | 64–>64 | >64 | >64 | |
| ITCZ | 0.25–4 | 1 | 2 | |
| AMPH-B | 1–4 | 2 | 4 | |
a
Microtiter plates were shaken and 0.1-ml samples were transferred to SD agar plates, which were incubated for more than 72 hours at 35°C.