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. 2022 Mar 11;13:867015. doi: 10.3389/fimmu.2022.867015

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Copyright © 2022 Bjornson-Hooper, Fragiadakis, Spitzer, Chen, Madhireddy, Hu, Lundsten, McIlwain and Nolan

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Neutrophil Ki67 induction (mean and standard error of differences of ArcSinh-transformed values) by species after exposure to 22M CFU of gamma-irradiated Bacillus anthracis for 15 minutes. (B) CD1c+ B cells are more abundant in non-human primates than in humans, and CD1c is furthermore expressed at higher levels in NHP B cells, especially in macaques. Left: Abundance of CD1c+ B cells (expressed as % of total B cells) in each species. Middle and right: One representative individual from each species. Dot plots show 500 randomly selected B cells (middle) or 250 randomly selected CD11b-/CD16- DCs (right). Statistics (A, B): Groups were compared using a one-tailed Mann-Whitney U test with asterisks indicating significant differences (*p < 5x10^-2, **p < 1x10^-2, ***p < 1x10^-3).