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. 2022 Mar 29;2022(3):CD010893. doi: 10.1002/14651858.CD010893.pub4

Comparison 1. Colchicine versus placebo.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1.1 Number of participants experiencing an attack 2   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
1.1.1 Colchicine 0.6 mg orally 3 times daily (at 3 months) 1 10 Risk Ratio (M‐H, Fixed, 95% CI) 0.21 [0.05, 0.95]
1.1.2 Colchicine 0.5 mg orally twice daily (at 2 months) 1 20 Risk Ratio (M‐H, Fixed, 95% CI) 0.78 [0.49, 1.23]
1.1.3 Sensitivity analysis for colchicine 0.5 mg orally twice daily (at 2 months) – assumed with attack 1 22 Risk Ratio (M‐H, Fixed, 95% CI) 0.74 [0.50, 1.08]
1.1.4 Sensitivity analysis for colchicine 0.5 mg orally twice daily (at 2 months) – assumed without attack 1 22 Risk Ratio (M‐H, Fixed, 95% CI) 0.78 [0.46, 1.32]