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. 2022 Mar 29;2022(3):CD010893. doi: 10.1002/14651858.CD010893.pub4

Comparison 6. Colchicine single dose versus divided dose.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
6.1 Duration of attacks 1   Mean Difference (IV, Fixed, 95% CI) Subtotals only
6.1.1 Duration of attacks at 3 months (hours) 1 79 Mean Difference (IV, Fixed, 95% CI) ‐0.04 [‐10.91, 10.83]
6.1.2 Duration of attacks at 6 months (hours) 1 79 Mean Difference (IV, Fixed, 95% CI) 2.80 [‐5.39, 10.99]
6.2 Adverse drug reactions at 3 months 1   Odds Ratio (M‐H, Fixed, 95% CI) Subtotals only
6.2.1 Anorexia 1 79 Odds Ratio (M‐H, Fixed, 95% CI) 1.94 [0.53, 7.07]
6.2.2 Nausea 1 79 Odds Ratio (M‐H, Fixed, 95% CI) 0.43 [0.04, 4.91]
6.2.3 Diarrhea 1 79 Odds Ratio (M‐H, Fixed, 95% CI) 1.94 [0.53, 7.07]
6.2.4 Abdominal pain 1 79 Odds Ratio (M‐H, Fixed, 95% CI) 0.87 [0.20, 3.75]
6.2.5 Vomiting 1 79 Odds Ratio (M‐H, Fixed, 95% CI) 0.57 [0.09, 3.59]
6.2.6 Elevated ALT 1 79 Odds Ratio (M‐H, Fixed, 95% CI) 0.87 [0.20, 3.75]
6.2.7 Elevated AST 1 79 Odds Ratio (M‐H, Fixed, 95% CI) 0.71 [0.22, 2.36]
6.3 Adverse drug reactions at 6 months 1   Odds Ratio (M‐H, Fixed, 95% CI) Subtotals only
6.3.1 Anorexia 1 79 Odds Ratio (M‐H, Fixed, 95% CI) 1.03 [0.31, 3.41]
6.3.2 Nausea 1 79 Odds Ratio (M‐H, Fixed, 95% CI) 0.43 [0.04, 4.91]
6.3.3 Diarrhea 1 79 Odds Ratio (M‐H, Fixed, 95% CI) 0.88 [0.05, 14.55]
6.3.4 Abdominal pain 1 79 Odds Ratio (M‐H, Fixed, 95% CI) 1.53 [0.34, 6.90]
6.3.5 Vomiting 1 79 Odds Ratio (M‐H, Fixed, 95% CI) 0.17 [0.01, 3.59]
6.3.6 Elevated ALT 1 79 Odds Ratio (M‐H, Fixed, 95% CI) 2.77 [0.28, 27.84]
6.3.7 Elevated AST 1 79 Odds Ratio (M‐H, Fixed, 95% CI) 0.86 [0.23, 3.26]
6.4 Acute‐phase response 2   Mean Difference (IV, Fixed, 95% CI) Subtotals only
6.4.1 ESR (mm/hour) 1 39 Mean Difference (IV, Fixed, 95% CI) 2.00 [‐4.33, 8.33]
6.4.2 WBC count (109/L) 1 39 Mean Difference (IV, Fixed, 95% CI) ‐0.60 [‐4.06, 2.86]
6.4.3 Fibrinogen (mg/dL) 1 39 Mean Difference (IV, Fixed, 95% CI) 27.00 [‐4.45, 58.45]
6.4.4 CRP (mg/L) 1 39 Mean Difference (IV, Fixed, 95% CI) ‐1.00 [‐2.59, 0.59]
6.4.5 SAA (mg/L) 1 79 Mean Difference (IV, Fixed, 95% CI) 0.00 [‐1.52, 1.52]