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#1 exp Familial Mediterranean Fever/ #2 (familial mediterranean fever or familial paroxysmal polyserositi* or FMF).ti,ab,kw. #3 1 or 2 #4 exp Colchicine/ or exp Interleukin 1 Receptor Antagonist Protein/ or exp Etanercept/ or exp Infliximab/ or exp Adalimumab/ or exp Anakinra/ or exp Adalimumab/ or exp Interferon‐alpha/ or exp Thalidomide/ #5 (colchicine or anakinra or rilonacept or canakinumab or etanercept or infliximab or adalimumab or tocilizumab or interferon‐alpha or INF‐alpha or INF‐a or thalidomide or ImmunoGuard or Immuno‐Guard).ti,ab,kw. #6 4 or 5 #7 randomized controlled trial.pt. #8 controlled clinical trial.pt. #9 randomized.ab. #10 placebo.ab. #11 clinical trials as topic/ #12 randomly.ab. #13 (crossover or cross‐over).tw. #14 trial.ti. #15 7 or 8 or 9 or 10 or 11 or 12 or 13 or 14 #16 humans/ #17 15 and 16 #18 3 and 6 and 17