| Domain |
Description |
| Selection bias |
| Random sequence generation |
Inadequate generation of the randomisation sequence |
| Allocation concealment |
Inadequate concealment of allocations prior to assignment |
| Performance bias |
| Blinding of participants and personnel |
Knowledge of the allocated interventions by participants and personnel during the study |
| Detection bias |
| Blinding of outcome assessment |
Knowledge of the allocated interventions by outcome assessors |
| Attrition bias |
| Incomplete outcome data |
Amount, nature, or handling of incomplete outcome data |
| Reporting bias |
| Selective reporting |
When all prespecified outcomes that are of interest in the review have not been reported |
| Other bias |
| Other sources of bias |
Any other problems not covered elsewhere |
