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. 2022 Mar 29;2022(3):CD006430. doi: 10.1002/14651858.CD006430.pub3

Lin 2014.

Study characteristics
Methods Design: RCT
Duration of trial: 15/16 months (July 2011 to November 2012)
Unit of randomisation: people with stroke of 6–10 months' duration with executive function and memory deficits; aged 45–70 years
Recruitment and allocation: patients attending a rehabilitation hospital were recruited and randomly allocated to 1 of 2 groups: IG (n = 16) and CG (n = 18)
Participants Setting: rehabilitation department of 1 rehabilitation hospital
Country: China
Sample size: 34 adults, 59% men; IG: 16; CG: 18
Inclusion criteria: confirmed diagnosis of first stroke; deficits in both executive function and memory (z‐scores < 1.5 in the Wechsler Memory Scale memory quotient and TMT); right handed; education ≥ 8 years; time since stroke 6–10 months (180–300 days); aged 45–70 years; normal hearing and vision
Exclusion criteria: mental retardation; history of Alzheimer's disease or mental illness such as schizophrenia before stroke; vital organ failure; concomitant antidepressant, psychoactive drug, or steroid therapy
Age: mean: IG: 62.4 (SD 6.0) years; CG: 63.2 (SD 5.7) years
Time since onset of stroke: mean: IG: 227.5 (SD 24.0) days; CG: 228.1 (SD 18.4) days
Types of stroke: not reported
Site of lesion: n (left/right hemisphere): IG: 6/10; CG: 9/9
Interventions Intervention group
Brief name: RehaCom
Recipients: adults in rehabilitation 6–10 months since stroke with executive function and memory deficits.
Why: to improve executive function and memory.
What (materials): RehaCom software; see hasomed.de/en/products/rehacom/; the software is available in 27 languages at no extra cost; computer.
What (procedures): CT; no further description of procedures provided.
Who provided: 2 trained psychologists; the RehaCom website states that the software is used "extensively by … occupational therapists" and other clinicians in rehabilitation centres, hospitals, and clinics.
How: not described but presumably face‐to‐face
Where: not described but presumably in the rehabilitation department
When and how much: 1 hour per session, 6 sessions per week for 10 weeks (60 hours in total)
Tailoring: none reported
Modifications: none reported
How well (planned): none reported
How well (actual): none reported
Comparator group
Brief name: CG
Recipients: adults in rehabilitation 6–10 months since stroke with executive function and memory deficits
Why: to provide rehabilitation.
What: not described except that no CT was provided.
Who provided: not reported
How: not reported
Where: not reported, presumably within the rehabilitation department
When and how much: not reported
Tailoring: none reported
Modifications: none reported
How well (planned): not reported
How well (actual): not reported
Outcomes Primary: none
Secondary
  • Wechsler Memory Scale

    • Orientation

    • Mental control

    • Logical memory

    • Digits forward and backward

  • Memory Quotient

  • TMT‐A

  • TMT‐B


Other
  • Wechsler Memory Scale

    • Information

  • Visual reproduction

  • Associated learning

  • Resting state functional magnetic resonance imaging


Methods of data collection: neuropsychological assessments performed by 2 trained psychologists who were blinded to group assignment.
Data collection time points: baseline and after intervention (10 weeks)
Notes Funding: yes
Conflict of interest: none
Published trial protocol: none located
Trial registration: none reported
Ethics approval: yes
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Low risk Used random number table.
Allocation concealment (selection bias) Unclear risk Method of allocation not reported.
Blinding of participants and personnel (performance bias)
All outcomes High risk Blinding or not was not reported but it was apparent that participants could have known which group they were allocated to.
Blinding of outcome assessment (detection bias)
All outcomes Low risk Neuropsychological assessments were performed by 2 trained psychologists who were blinded to group assignment.
Incomplete outcome data (attrition bias)
All outcomes Unclear risk Number randomised was unclear, just the number who completed the study was reported.
Selective reporting (reporting bias) Low risk It appears that all planned outcomes were reported.
Other bias Low risk No other identifiable bias.