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. Author manuscript; available in PMC: 2022 Mar 29.
Published in final edited form as: Cell Stem Cell. 2020 Nov 11;28(2):315–330.e5. doi: 10.1016/j.stem.2020.10.006

Figure 2: scRNA-Seq of the human TM.

Figure 2:

(A) UMAPs of clusters identified in a human TM, analyzed with the CellFindR algorithm. (B) UMAPs of the keratinocytes re-clustered independent from other cell types. Dendrogram inset was created with Morpheus and the top 50 significantly differentially upregulated genes in each group (“Morpheus,” n.d.). (C) Heat-map showing expression of genes associated with proliferation and differentiation in the keratinocyte clusters. Each column is a cell. (D) Top MSigDB gene sets enriched for genes at least 1.5-fold and significantly upregulated in human keratinocyte cluster 2 relative to the other keratinocytes. (E) Violin plots of expression of ITGB1, CAV1, KRT17, TAGLN, TNFRSF12A, TPM4, WDR1, and SLC7A5 in the keratinocyte clusters. p values are for expression in cluster 2 relative the rest of the keratinocyte dataset. See also Tables S3–4.