Table 1.
Formulation composition of Apigenin-loaded hybrid nanoparticles and their effects on particle size, encapsulation efficiency and drug release.
| Code | Formulation Variables | Responses | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Lecithin (A) (mg) |
Chitosan (B) (mg) | TPGS (C) (%) | Particle Size (nm) |
Encapsulation Efficiency (%) |
Drug Release (%) |
||||
| Actual | Predicted | Actual | Predicted | Actual | Predicted | ||||
| Value | Value | Value | Value | Value | Value | ||||
| F1 | 80 | 20 | 0.75 | 101.28 | 103.13 | 52.65 | 53.80 | 36.47 | 37.61 |
| F2 | 180 | 20 | 0.75 | 171.32 | 170.53 | 63.12 | 62.61 | 60.40 | 63.41 |
| F3 | 80 | 60 | 0.75 | 190.04 | 189.83 | 68.23 | 70.14 | 56.60 | 58.59 |
| F4 | 180 | 60 | 0.75 | 227.24 | 225.39 | 79.54 | 77.95 | 53.53 | 55.39 |
| F5 | 80 | 40 | 0.5 | 162.29 | 160.88 | 60.4 | 63.39 | 52.75 | 54.46 |
| F6 | 180 | 40 | 0.5 | 201.21 | 204.43 | 71.04 | 70.19 | 62.51 | 60.35 |
| F7 | 80 | 40 | 1 | 175.21 | 174.99 | 64.54 | 63.56 | 56.50 | 55.66 |
| F8 | 180 | 40 | 1 | 245.00 | 244.40 | 71.34 | 73.36 | 67.11 | 65.39 |
| F9 | 130 | 20 | 0.5 | 131.58 | 133.14 | 56.32 | 57.12 | 54.78 | 53.13 |
| F10 | 130 | 60 | 0.5 | 204.75 | 203.37 | 74.12 | 73.46 | 58.63 | 56.93 |
| F11 | 130 | 20 | 1 | 159.25 | 156.63 | 61.56 | 60.29 | 57.38 | 55.07 |
| F12 | 130 | 60 | 1 | 230.52 | 231.96 | 77.13 | 76.63 | 66.19 | 64.04 |
| F13 * | 130 | 40 | 0.75 | 184.05 | 185.75 | 67.78 | 66.88 | 59.32 | 58.60 |
| F14 * | 130 | 40 | 0.75 | 187.43 | 185.75 | 67.23 | 66.88 | 58.45 | 58.60 |
| F15 * | 130 | 40 | 0.75 | 185.76 | 185.75 | 68.13 | 66.88 | 58.04 | 58.60 |
* center point.