TABLE 2.

Concentrations of rufloxacin in CSF and plasma, and CSF/plasma concentration ratios

Group and sample	n	Rufloxacin concn (μg/ml), mean ± SD (range)		CSF/plasma ratio (%), mean ± SD (range)
		In CSF	In plasma
A1d, day 1	10	1.66 ± 0.61 (0.76–2.82)	3.02 ± 1.15 (1.61–5.37)	0.61 ± 0.31 (0.29–1.21)
A7d, day 7	10	1.97 ± 0.57 (1.06–2.77)	3.37 ± 1.19 (1.78–5.08)	0.60 ± 0.12 (0.48–0.84)
B
Day 1	13	1.98 ± 1.17 (0.20–4.97)	3.46 ± 1.78 (0.35–7.29)	0.57 ± 0.12 (0.41–0.82)
Day 7	11	3.16 ± 0.85 (1.81–4.97)	5.43 ± 2.23 (3.10–10.79)	0.61 ± 0.13 (0.46–0.84)
C
Day 1	10	2.93 ± 0.91 (1.94–4.35)	4.15 ± 1.24 (2.38–6.41)	0.72 ± 0.13 (0.55–0.97)
Day 4	10	2.90 ± 0.99 (1.58–4.99)	3.48 ± 0.83 (1.83–4.68)	0.84 ± 0.20 (0.49–1.11)
Day 7	10	2.47 ± 0.76 (1.59–3.94)	3.29 ± 1.05 (1.92–4.60)	0.83 ± 0.45 (0.36–1.99)