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. 2022 Mar 11;16:833630. doi: 10.3389/fnins.2022.833630

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Copyright © 2022 Ramya, Shyam, Kowsalya, Balavigneswaran and Kadalmani.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Lauric acid (LA) induces ROS-mediated apoptosis in SH-SY5Y cells but 3T3 cells are less affected. Bar chart indicating the cellular ROS production (A) proportionate to cell death (B) at varying LA concentrations. LA modulates antioxidant and inflammatory genes differentially. SH-SY5Y cells were treated with LA (0, 1, 10, and 100 μg/mL), total RNA was isolated, reverse transcribed to cDNA and analyzed by qPCR for expression of antioxidant genes GCLC (C), HO-1 (D), Nqo1 (E), and anti-inflammatory genes IL6 (F), TNFα (G), iNOS (H). (I) Gene expression profiling of LA mediated transcript modulation. Each experiment was repeated at least with three parallel replicates. GAPDH was used as the control. Data represent mean ± SD (n = 3); *p < 0.05, **p < 0.001, ***p < 0.0001.