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. Author manuscript; available in PMC: 2023 Apr 1.
Published in final edited form as: Gastroenterology. 2022 Jan 6;162(4):1319–1333. doi: 10.1053/j.gastro.2021.12.281

Figure 3. The PSCA CAR_s15 vector increases NK cell functional markers without decreasing the native activation receptors.

Figure 3.

(A) Flow cytometry analysis of NKp30, NKp44, NKp46, NKG2D, and CD16 on the CD 56(+) s15 or PSCA CAR_s15 NK cells stimulated with Capan-1 cells with an E:T cell ratio of 1:3 measured after 24 hours of co-culture. (B) Flow cytometry analysis of intracellular TNF-α, IFNγ, and CD107a on engineered CD56(+) NK cells without or with stimulation by Capan-1 cells. (C) Quantification of the results shown in panel B (n=3). P-values were determined by the t-test.