TABLE 3.
Lack of correlation of antiviral efficacy in MDCK cells and response to zanamivir therapy in humansa
Subject and day (D) | Plaque reduction IC50 (μg/ml) | Pretreatment titer (log10 TCID50/ml) | Day virus undetectable |
---|---|---|---|
7222 D1 | 0.04 | 5.8 | 3 |
7228 D1 | 0.04 | 5.8 | 4 |
7232 D1 | 0.04 | 5.05 | 4 |
7240 D1 | >100 | 6.05 | 2 |
7241 D1 | >100 | 4.05 | 2 |
7249 D1 | >100 | 4.3 | 5 |
7257 D1 | >100 | 4.05 | 3 |
7261 D1 | >100 | 4.8 | 2 |
Subjects enrolled in the NAIB2008 clinical study were placed in a treatment group receiving IH plus IN zanamivir QID.