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. 2000 Jan;44(1):78–87. doi: 10.1128/aac.44.1.78-87.2000

TABLE 3.

Lack of correlation of antiviral efficacy in MDCK cells and response to zanamivir therapy in humansa

Subject and day (D) Plaque reduction IC50 (μg/ml) Pretreatment titer (log10 TCID50/ml) Day virus undetectable
7222 D1 0.04 5.8 3
7228 D1 0.04 5.8 4
7232 D1 0.04 5.05 4
7240 D1 >100 6.05 2
7241 D1 >100 4.05 2
7249 D1 >100 4.3 5
7257 D1 >100 4.05 3
7261 D1 >100 4.8 2
a

Subjects enrolled in the NAIB2008 clinical study were placed in a treatment group receiving IH plus IN zanamivir QID. 

HHS Vulnerability Disclosure