TABLE 4.
Efficacy of IN zanamivir in ferrets following infection with day 2 isolate from subject 2871 (virus 2871 D2)a
| Treatment dose (mg/kg) | No. of animals with pyrexia/no. treated | Mean body temperature AUC (% control) | Mean nasal-wash virus AUC (TCID50) | Mean nasal-wash virus titer (% of control)b | Mean nasal-wash turbidity (% of control) |
|---|---|---|---|---|---|
| 1.0 | 0/4 | 3.3* | 4.93 | 10.57** | 65.4 |
| 0.1 | 0/4 | 6.8* | 5.17 | 18.62*** | 80.4 |
| 0.01 | 4/4 | 52.0* | 5.79 | 77.65 | 103.7 |
| Vehicle | 4/4 | 100 | 5.90 | 100 | 100 |
a
*, significantly different from untreated control (P = 0.01 by Duncan's multiple range test); **, significantly different from untreated control (P ≤ 0.01 by Dunnett's test); ***, significantly different from untreated control (P ≤ 0.05 by Dunnett's test).
b
Virus titrated in triplicate for each time point for individual ferrets.