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. 2000 Jan;44(1):78–87. doi: 10.1128/aac.44.1.78-87.2000

TABLE 5.

Efficacy of IN zanamivir in ferrets following infection with day 1 isolate from subject 7241 (virus 7241 D1)a

Treatment dose (mg/kg) No. of animals with pyrexia/no. treated Mean body temperature AUC (% control) Mean nasal-wash virus AUC (TCID50) Mean nasal-wash virus titer (% of control)b Mean nasal-wash turbidity (% of control)
1.0 0/4 12.01* 2.97 1.83** 73.81
0.1 4/4 33.49* 3.43 3.99** 79.76
0.01 4/4 65.09* 3.64 15.63** 92.26
Vehicle 4/4 100 4.91 100 100
a

*, significantly different from untreated control (P = 0.01 by Duncan's multiple range test); **, highly significantly different from untreated control (P ≤ 0.01 by Dunnett's test). 

b

Virus titrated in triplicate for each time point for individual ferrets. 

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