TABLE 5.
Efficacy of IN zanamivir in ferrets following infection with day 1 isolate from subject 7241 (virus 7241 D1)a
Treatment dose (mg/kg) | No. of animals with pyrexia/no. treated | Mean body temperature AUC (% control) | Mean nasal-wash virus AUC (TCID50) | Mean nasal-wash virus titer (% of control)b | Mean nasal-wash turbidity (% of control) |
---|---|---|---|---|---|
1.0 | 0/4 | 12.01* | 2.97 | 1.83** | 73.81 |
0.1 | 4/4 | 33.49* | 3.43 | 3.99** | 79.76 |
0.01 | 4/4 | 65.09* | 3.64 | 15.63** | 92.26 |
Vehicle | 4/4 | 100 | 4.91 | 100 | 100 |
*, significantly different from untreated control (P = 0.01 by Duncan's multiple range test); **, highly significantly different from untreated control (P ≤ 0.01 by Dunnett's test).
Virus titrated in triplicate for each time point for individual ferrets.