Fig. 6.
The estimated discretized DFE (distribution of deleterious fitness effects) across variants (Keightley and Eyre-Walker 2007; Eyre-Walker and Keightley 2009) for each gene class with the proportion of mutation with Nes values in each category. Both the control, and especially the male and female-biased gene classes, showed an upward bias for weakly deleterious mutations. Significant differences between individual DFEs were assessed using a likelihood-ratio test, wherein a model containing both control and class-specific genes as a single group and a model of each gene class having its own DFE were compared, with two degrees of freedom. A similar test was conducted between male and female-biased gene classes.