Figure 8.
Administered equivalent dose (AED, mg/kg body weight) values of the test chemicals for specific endpoints in KGN cells (A), MA-10 cells (B), and C18-4 cells (C). AEDs were calculated by dividing the benchmark concentrations ( μM) by steady-state concentrations (Css) of the chemicals. Data points and error bars represent means ± upper and lower limits; n = 6–8. Some error bars cannot be shown because they were shorter than the size of symbols. The AEDs of isopropylated triphenyl phosphate (IPPP), tris(2,4-di-tert-butylphenyl) phosphate (TDtBPP), and 2,4-bis(1,1-dimethylethyl)-phenol phosphate (BDMPP) are not calculated due to their high octanol-water partition coefficient (LogKow) and/or they are not applicable for the in vitro to in vivo extrapolation prediction algorithms.