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. 2022 Mar 11;15:811441. doi: 10.3389/fnmol.2022.811441

FIGURE 5.

FIGURE 5

SOM+ neurons in the spinal cord of Slack–/– mice exhibit enhanced frequency of spontaneous EPSCs. (A) Representative EPSCs of SOM+ neurons in WT (black) and Slack–/– (red) mice. (B) Averaged spontaneous EPSC frequencies (WT, n = 12, 27.2 ± 9.3 times/per min, 3 mice, age 11–13 weeks; Slack–/–, n = 14, 88.7 ± 19.7 times/per min, 4 mice, age 11–13 weeks; P = 0.014). (C) Amplitudes of sEPSCs of SOM+ neurons in WT and Slack–/– mice (WT, 12 cells, 479 events, –8.9 ± 0.43 pA; Slack–/–, 14 cells, 1356 events, –13.7 ± 1.9 pA; P = 0.011). (D) Typical spontaneous EPSCs from SOM+ neurons in WT (black) and Slack–/– (red) mice. (E) The averaged activation time course of spontaneous EPSCs from SOM+ neurons in WT and Slack–/– mice (WT, n = 12, 0.88 ± 0.08 ms; Slack–/–, n = 14, 0.91 ± 0.08 ms; P = 0.82). (F) Deactivation time course values of spontaneous EPSCs from SOM+ neurons in WT and Slack–/– mice (WT, n = 12, 16.9 ± 3.77 ms; Slack–/–, n = 14, 35.8 ± 5.25 ms; unpaired T-test; P = 0.037). (G) Half width of spontaneous EPSCs from SOM+ neurons in WT and Slack–/– mice (WT, n = 12, 4.77 ± 0.8 ms; Slack–/–, n = 14, 7.58 ± 0.8 ms; P = 0.001). *p < 0.05.