TABLE 2.
WT |
Slack–/–+GFP |
Slack–/–+KCNT1 |
|||||||
mean | SEM | n | mean | SEM | n | mean | SEM | n | |
Rheobase (pA) | 12.00 | 2.91 | 12 | 1.14 | 2.04 | 35 | 9.23 | 3.09 | 13 |
Normalized AHP amplitude | 1.00 | 0.10 | 12 | 0.87 | 0.04 | 32 | 0.88 | 0.08 | 13 |
RMP (mV) | –51.72 | 1.31 | 18 | –44.38 | 0.95 | 34 | –48.64 | 1.04 | 14 |
−20 pA AP count | 0 | 0 | 12 | 0.11 | 0.06 | 35 | 0 | 0 | 13 |
−10 pA AP count | 0.02 | 0.02 | 12 | 0.44 | 0.18 | 35 | 0.08 | 0.08 | 13 |
0 pA AP count | 0.21 | 0.16 | 12 | 1.43 | 0.35 | 35 | 0.73 | 0.35 | 13 |
10 pA AP count | 1.27 | 0.46 | 12 | 3.75 | 0.54 | 35 | 2.10 | 0.58 | 13 |
20 pA AP count | 2.87 | 0.78 | 12 | 6.25 | 0.78 | 35 | 4.13 | 0.84 | 13 |
30 pA AP count | 4.88 | 1.18 | 12 | 9.38 | 0.98 | 35 | 6.04 | 1.05 | 13 |
40 pA AP count | 6.28 | 1.23 | 12 | 12.34 | 1.11 | 35 | 8.51 | 1.28 | 13 |
50 pA AP count | 7.92 | 1.50 | 12 | 14.27 | 1.10 | 35 | 10.25 | 1.59 | 13 |
60 pA AP count | 8.81 | 1.55 | 12 | 15.76 | 1.17 | 35 | 11.68 | 1.72 | 13 |
70 pA AP count | 9.69 | 1.39 | 12 | 17.02 | 1.14 | 35 | 12.06 | 1.84 | 13 |
80 pA AP count | 9.91 | 1.24 | 12 | 17.82 | 1.19 | 35 | 13.06 | 1.83 | 13 |
90 pA AP count | 11.08 | 1.31 | 12 | 18.89 | 1.21 | 35 | 13.66 | 1.76 | 13 |
100 pA AP count | 11.76 | 1.39 | 12 | 20.17 | 1.28 | 35 | 14.91 | 1.80 | 13 |
110 pA AP count | 11.81 | 1.44 | 12 | 20.94 | 1.38 | 35 | 15.85 | 1.78 | 13 |
120 pA AP count | 12.50 | 1.39 | 12 | 21.64 | 1.25 | 35 | 16.28 | 1.87 | 13 |
PWL, Paw Withdrawal Latency; AHP, Afterhyperpolarization; RMP, Resting Membrane Potential; AP, Action Potential; s-EPSCs, Spontaneous Excitatory Postsynaptic Current.