Table 1.
Genome-wide significant disease susceptibility loci for BD.
| Year | Author | Population | Gene |
|---|---|---|---|
| 2009 | Meguro et al. (19) | Japanese | HLA-A26 |
| 2010 | Mizuki et al. (20) | Japanese | IL10 , IL23R |
| 2010 | Remmers et al. (21) | Turkish, mixed populations | IL10 , IL23R |
| 2012 | Hou et al. (22) | Chinese Han | STAT4 |
| 2013 | Kirino et al. (23) | Turkish, Japanese | CCR1-CCR3 , STAT4, KLRC4, ERAP1 |
| 2013 | Kirino et al. (17) | Turkish | MEFV M694V |
| 2013 | Lee et al. (24) | Korean, Japanese | GIMAP |
| 2014 | Ombrello et al. (18) | Turkish | HLA-A03 |
| 2014 | Xavier et al. (25) | Iranian | FUT2 |
| 2015 | Kappen JH et al. (26) | Turkish and mixed populations | IL12A |
| 2017 | Takeuchi et al. (27) | Turkish, Japanese, Iranian |
IL1B
, IRF8
, RIPK2, EGR2, LACC1, PTPN1 |
| 2020 | Ortiz Fernández et al. (28) | Turkish, Japanese etc. | IFNGR1 , DKK1 |
The genes highlighted in bold are the ones that we focused on in this paper as being related to macrophage and monocyte function.