. 2022 Mar 11;13:808622. doi: 10.3389/fphys.2022.808622

TABLE 5.

Relevant risk factors concerning cardiovascular and hypertensive clients/patients before BFRT.

Patient’s Name:______________________________________________________________________________ Age:________________________________________________________________________________________ Sex:________________________________________________________________________________________
□ Acute myocarditis; □ Acute systemic illness; □ Angina or ischemic ST depression at a workload < 6 METs; □ Angiotomography of the coronary arteries with the presence of plaque; □ Aortic syndrome or venous thromboembolism; □ Cardiomyopathy with ejection fraction < 30%; □ Class III or IV heart failure; □ Complex ventricular arrhythmias not well controlled; □ Congenital heart disease; □ Coronary revascularization (percutaneous coronary interventions, coronary by-pass graft surgery, and other arterial revascularization procedure); □ Electrocardiographic alterations at rest or during effort; □ Endocarditis, or pericarditis; □ Exercise capacity < 6 METs; □ Fall in systolic blood pressure below resting levels during exercise; □ Familial hypercholesterolemia with atherosclerotic cardiovascular disease or with another major risk; □ Marked elevated single risk factors, in particular total cholesterol (>310 mg/dL), LDL-C (>190 mg/dL), or blood pressure ≥ 180/110 mmHg; □ Multivessel coronary disease with two major epicardial arteries having 50% of stenosis; □ Myocardial infarction and unstable angina; □ Non-sustained ventricular tachycardia with exercise; □ Peripheral artery disease; □ Postural hypotension (20 mmHg drop in systolic blood pressure with symptoms of dizziness or light-headedness); □ Presence of abdominal aortic aneurysm; □ Previous episode of primary cardiac arrest (e.g., cardiac arrest that did not occur in the presence of an acute myocardial infarction or during a cardiac procedure); □ Recent myocardial infarction < 3 months; □ SBP ≥ 160 mmHg and/or DBP ≥ 100 mmHg prior to exercise; □ SBP between 130 and 139 mmHg or DBP between 85 and 89 mmHg with target organ damage^b, chronic kidney disease or diabetes mellitus; □ SBP between 140 and 159 mmHg or DBP between 90 and 99 mmHg with the presence of three or more cardiovascular risk factors^a, with target organ damage^b, chronic kidney disease or diabetes mellitus; □ SBP between 160 and 179 mmHg or DBP between 100 and 109 mmHg with the presence of 1 cardiovascular risk factor^a, with target organ damage^b, chronic kidney disease or diabetes mellitus; □ Self-reported easy bruising (Ballas and Kraut, 2008); □ Severe and/or symptomatic valve disease; □ Severe pulmonary hypertension; □ Stable angina; □ Stroke; □ Transient ischemic attack; □ Uncontrolled dysrhythmias; □ Unstable angina; □ Valvular heart disease with severe and asymptomatic valvular stenosis or regurgitation; □ Other medical condition that could be aggravated by exercise; □ A medical problem that the physician and BFR-user believe may be life-threatening;

Patient’s Name:______________________________________________________________________________
Age:________________________________________________________________________________________
Sex:________________________________________________________________________________________

□ Acute myocarditis;
□ Acute systemic illness;
□ Angina or ischemic ST depression at a workload < 6 METs;
□ Angiotomography of the coronary arteries with the presence of plaque;
□ Aortic syndrome or venous thromboembolism;
□ Cardiomyopathy with ejection fraction < 30%;
□ Class III or IV heart failure;
□ Complex ventricular arrhythmias not well controlled;
□ Congenital heart disease;
□ Coronary revascularization (percutaneous coronary interventions, coronary by-pass graft surgery, and other arterial revascularization procedure);
□ Electrocardiographic alterations at rest or during effort;
□ Endocarditis, or pericarditis;
□ Exercise capacity < 6 METs;
□ Fall in systolic blood pressure below resting levels during exercise;
□ Familial hypercholesterolemia with atherosclerotic cardiovascular disease or with another major risk;
□ Marked elevated single risk factors, in particular total cholesterol (>310 mg/dL), LDL-C (>190 mg/dL), or blood pressure ≥ 180/110 mmHg;
□ Multivessel coronary disease with two major epicardial arteries having 50% of stenosis;
□ Myocardial infarction and unstable angina;
□ Non-sustained ventricular tachycardia with exercise;
□ Peripheral artery disease;
□ Postural hypotension (20 mmHg drop in systolic blood pressure with symptoms of dizziness or light-headedness);
□ Presence of abdominal aortic aneurysm;
□ Previous episode of primary cardiac arrest (e.g., cardiac arrest that did not occur in the presence of an acute myocardial infarction or during a cardiac procedure);
□ Recent myocardial infarction < 3 months;
□ SBP ≥ 160 mmHg and/or DBP ≥ 100 mmHg prior to exercise;
□ SBP between 130 and 139 mmHg or DBP between 85 and 89 mmHg with target organ damage^b, chronic kidney disease or diabetes mellitus;
□ SBP between 140 and 159 mmHg or DBP between 90 and 99 mmHg with the presence of three or more cardiovascular risk factors^a, with target organ damage^b, chronic kidney disease or diabetes mellitus;
□ SBP between 160 and 179 mmHg or DBP between 100 and 109 mmHg with the presence of 1 cardiovascular risk factor^a, with target organ damage^b, chronic kidney disease or diabetes mellitus;
□ Self-reported easy bruising (Ballas and Kraut, 2008);
□ Severe and/or symptomatic valve disease;
□ Severe pulmonary hypertension;
□ Stable angina;
□ Stroke;
□ Transient ischemic attack;
□ Uncontrolled dysrhythmias;
□ Unstable angina;
□ Valvular heart disease with severe and asymptomatic valvular stenosis or regurgitation;
□ Other medical condition that could be aggravated by exercise;
□ A medical problem that the physician and BFR-user believe may be life-threatening;

^aMen ≥ 55 years or women ≥ 65 years; History of premature CVD in 1st degree relatives: men < 55 years old or women < 65 years old; Smoking; Dyslipidemia: total cholesterol > 190 mg/dL and/or LDL-cholesterol > 115 mg/dL and/or HDL-cholesterol < 40 mg/dL in men or < 46 mg/dL in women and/or Triglycerides > 150 mg/dL; Insulin resistance: fasting plasma glucose between 100 and 125 mg/dL, oral glucose tolerance test between 140 and 199 mg/dL in 2 h, glycated hemoglobin between 5.7 and 6.4%; Obesity: BMI ≥ 30 kg/m², waist circumference ≥ 102 cm for men or ≥ 88 cm for women. ^bLeft ventricular hypertrophy; Carotid artery intima-media thickness > 0.9 mm or carotid plaque; Carotid-femoral pulse wave velocity > 10 m/s; Ankle-brachial index < 0.9; Stage 3 chronic kidney disease; Albuminuria between 30 and 300 mg/24 h or albumin-creatinine ratio urinary 30–300 mg/g. SBP, systolic blood pressure; DBP, diastolic blood pressure; CVD, cardiovascular disease; LDL, low density lipoprotein; HDL, high density lipoprotein; BMI, body mass index. Adapted from previous studies (Fletcher et al., 2001; Milech et al., 2016; Diabetes, 2019; Mach et al., 2020; Pelliccia et al., 2021).