Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Mar 11;12:803082. doi: 10.3389/fcimb.2022.803082

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2022 Chen, Rong, Sun, Zou, Zhao and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Changes in the gut microbiota after LPS challenge in the TMAO-induced frailty model. Serum samples were collected after 4-week administration of TMAO or 72 h after LPS challenge. (A) Shannon indices of gut microbiota alpha-diversity in the control (blue), control + LPS (green), TMAO (orange), and TMAO + LPS (red) groups. (B) Graphic PCoA of the control (blue dots), control + LPS (yellow triangles), TMAO (red squares), and TMAO + LPS groups (green diamonds) at the OTU level. (C) Average relative abundance of prevalent microbiota at the genus level in the control and control + LPS groups. (D) Average relative abundance of prevalent microbiota at the genus level in the TMAO and TMAO + LPS groups. (E) Taxonomic cladogram obtained from LEfSe analysis showing the distribution of bacterial taxa (phylum, class, and order) that were differentially abundant in the control and control + LPS groups. Green (red) indicates increased abundance in the control group (control + LPS group). (F) Taxonomic cladogram obtained from LEfSe analysis showing the distribution of bacterial taxa (phylum, class, and order) that were differentially abundant in the TMAO and TMAO + LPS groups. Green (red) indicates increased abundance in the TMAO group (TMAO + LPS group). *p <0.05, Ns indicates not significant, Wilcoxon rank-sum test.