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. 2022 Mar 29;17(3):e0265961. doi: 10.1371/journal.pone.0265961

Fig 8. Photomicrographs of CREB immune-stained sections of frontal cortex and hippocampus.

Fig 8

(a-b) Sham-operated group showing marked expression of CREB. (c-d) OVC/D-gal group showing diminished CREB expression among the neuronal cells. AD-model rats’ which treated with AM1241, (e-f) 3mg/kg and (g-h) 6mg/kg showing restored boosted expression of CREB. (i) Image analysis software for quantification of the positive expression of CREB (data were analyzed by using one way ANOVA followed by Tukey’s post hoc test. Values expressed as mean ± SE (n = 5 rats/group). *, #, and ± statistically significant different at P < 0.05, where; * statistically significant different comparing with control group, # statistically significant different comparing with OVC/D-gal group, ± statistically significant different comparing with AM1241 (3mg/Kg).