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. 2022 Mar 29;17(3):e0266135. doi: 10.1371/journal.pone.0266135

Fig 1. Extract screening reveals senolytic properties of ginger.

Fig 1

(A) WI-38 fibroblasts were left untreated (grey) or rendered senescent by exposure to ionizing radiation (IR, 10 Gy) followed by culture for an additional 10 days (red), whereupon cells were treated with the indicated extracts and dilutions for 24 h. (B) The impact on ginger extract on proliferating (grey) and senescent (red) cells on cell survival, assessed by the MTT cell viability assay. Data are represented as the mean and standard errors from biological replicates [senescent n = 9 and proliferating (1:500 (n = 4) and 1:200 (n = 7), (***p<0.005)]. (C) Cells that were prepared as in (A) were treated with ginger extract for 24 h or (D) 72 h followed by senescence-associated β-galactosidase (SA-βGal) staining.