Table 4.

Multivariable linear regression models evaluating the relationship of disease activity, represented by low DAS28ESR and CDAI at three sites: femoral neck, total hip and lumbar spine. All models control for the same variables in our primary model and were similarly weighted by number of study visits.

	Low DAS28ESR a,b			Low CDAI a,b
	β	95% CI	p-value	β	95% CI	p-value
Femoral Neckc	0.071	0.021 to 0.122	0.020	0.051	0.005 to 0.098	0.032
Total Hipc	0.071	0.021 to 0.122	0.006	0.085	0.038 to 0.132	0.001
Lumbar Spinec	0.060	−0.004 to 0.124	0.067	0.057	−0.005 to 0.118	0.069

-DAS28ESR: Disease activity score 28-joints with erythrocyte sedimentation rate; CDAI: clinical disease activity index; DXA: dual x-ray absorptiometry; RA: rheumatoid arthritis; anti-cyclic citrullinated peptide; bDMARD: biologic disease modifying anti-rheumatic drug; OP: osteoporosis; BMI: body mass index.

^a-Low DAS28ESR DAS28ESR ≤3.2 vs. moderate/high DAS28ESR >3.2.; Low CDAI <10 vs. high/moderate ≥10.

^b-Cumulative values calculated using trapezoidal area under the curve/observation time.

^c-Controlled for: age at DXA, female sex, race/ethnicity, RA duration, BMI, bDMARD use, Prednisone dose, ACPA positivity and OP medication use.