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. 2022 Mar 11;13:842092. doi: 10.3389/fgene.2022.842092

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Copyright © 2022 Jeppesen, Hjortshøj, Hindkjær, Hatt, Petersen, Singh, Schelde, Andreasen, Christensen, Lildballe and Vogel.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cell-free NIPT result for chromosome X and chromosome Y. The horizontal axis represents the normalized level of X-chromosomal material [NCV(X)], and the vertical axis represents level of Y-chromosomal material detected [NCV(Y)]. The normal range for female euploid samples (Normal XX) and male euploid samples (Normal XY) are marked by the dotted lines. The cell-free NIPT result for the reported case is marked with a black square. The cell-free NIPT result suggests a 47,XXY karyotype in at least one of the fetuses. NCV = Normalized Chromosome Value (for chromosome X and chromosome Y, respectively).