TABLE 1.
Patient demographics for clinical-pathologic diagnostic cohorts
| AR | CLAD/NRAD | INFXN | LB | Stable | Total | |
|---|---|---|---|---|---|---|
| Samples (patients) | 35 (29) | 26 (22) | 24 (20) | 11 (10) | 99 (66) | 195 (103) |
| Median age, y (IQR)a | 59 (55.0–67.0) | 60 (55.5–65.8) | 61.5 (56.2–65.2) | 60 (52.5–67.2) | 62 (55.2–68.8) | 62 (55.5–68.0) |
| Gender, n (%)a,b | ||||||
| Male | 20 (69) | 16 (73) | 14 (70) | 3 (30) | 35 (53) | 62 (60) |
| Female | 9 (31) | 6 (27) | 6 (30) | 7 (70) | 31 (47) | 41 (40) |
| Race/ethnicity (%)a | ||||||
| White/Caucasian | 27 (93.1) | 18 (81.8) | 19 (95.0) | 10 (100) | 62 (93.9) | 96 (93.2) |
| Black/AA | 2 (6.9) | 4 (18.2) | 1 (5.0) | 0 (0) | 3 (4.5) | 6 (5.8) |
| Hispanic/Latino | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 1 (1.5) | 1 (1.0) |
| Asian | 0 (0) | 0 (0) | 0(0) | 0 (0) | 0 (0) | 0(0) |
| Median time post-LT, d (IQR)a | 194 (39.0–293.0) | 385.5 (198.3–1133.0) | 110.5 (79.0–316.0) | 205 (155.0–369.0) | 184 (95.5–304.0) | 198 (91.5–357.5) |
| Reason for TBBxc | ||||||
| For cause | 8 (22.9) | 14 (53.8) | 3 (12.5) | 0 (0.0) | 4 (4.0) | 29 (14.9) |
| Surveillance | 27(77.1) | 12 (46.2) | 21 (87.5) | 11 (100) | 95 (96.0) | 166 (85.1) |
| Native diseasec (LAS categorical,d %) | ||||||
| A (obstructive) | 12 (34.3) | 10 (38.5) | 12 (50.0) | 9 (81.8) | 41 (41.4) | 84 (43.1) |
| B (vascular) | 2 (5.7) | 2 (7.7) | 1 (4.2) | 0 (0) | 7 (7.1) | 12 (6.2) |
| C (suppurative) | 1 (2.9) | 2 (7.7) | 0 (0) | 0 (0) | 2 (2.0) | 5 (2.6) |
| D (restrictive) | 20 (57.1) | 12 (46.2) | 11 (45.8) | 2 (18.2) | 49 (49.5) | 94 (48.2) |
| Transplant type, n (%)a,b | ||||||
| Single | 2 (6.9) | 4 (18.2) | 7 (35.0) | 2 (20) | 14 (21.2) | 22 (21.4) |
| Bilateral | 27 (93.1) | 18 (81.8) | 13 (65.0) | 8 (80.0) | 52 (78.8) | 81 (78.6) |
aValues reflect patient counts.
bCounts from individual categories do not add to total as samples from the same patient can be classified to different diagnostic categories.
cValues reflect sample counts.
dLAS ISHLT Native Lung Disease Category.
AR, acute rejection; CLAD/NRAD, chronic lung allograft dysfunction or neutrophilic-responsive allograft dysfunction; INFXN, infection; IQR, interquartile range; ISHLT, International Society of Heart and Lung Transplantation; LAS, lung allocation score; LB, lymphocytic bronchiolitis; LT, lung transplantation; TBBx, transbronchial lung biopsiy.