Table 1.

Biorisk management standard for poliovirus-essential facilities holding wild poliovirus materials¹⁸

Element	Notes/Key Challenges
Biorisk Management System	Oversight by Biorisk Management Committee, with expertise in biosafety, biosecurity, physical security, facility engineering, and occupational health
Risk Assessment	Written risk assessments must be developed for each laboratory protocol/method in the containment laboratory; risk mitigation plans
Poliovirus Inventory and Information	Accurate inventory of poliovirus infectious materials; periodic review of inventory
General Safety
Personnel and Competency	Recruitment, training, competence, continuity and succession planning
Good Microbiological Technique
Clothing and Personal Protective Equipment (PPE)
Human Factors	Institutional policies to address risk associated with human behavior
Health Care	Occupational health program, proof of poliovirus immunization and proof of immunity (requires neutralization assay)
Emergency Response and Contingency Planning	Anticipate all credible emergency scenarios; logistics for specimen collection and testing in the event of a release or laboratory exposure; coordination with local, state/provincial, and national emergency and public health authorities
Accident/Incident Investigation
Facility Physical Requirements	Facility design and verification; infrastructure and operations: emergency shower, effluent decontamination
Equipment and Maintenance
Decontamination, Disinfection, and Sterilization	Management of biological waste, inactivation of poliovirus (e.g. RNA extraction for downstream processes) by validated methods
Transport Procedures	Material transport within the facility and to/from other facilities
Security	Physical security, information security, personnel control, personal security, contractors/visitors/suppliers