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. Author manuscript; available in PMC: 2022 Mar 29.
Published in final edited form as: Osteoarthritis Cartilage. 2020 Feb 8;28(5):626–638. doi: 10.1016/j.joca.2020.01.015

Fig. 6. Effect of intra-articular macrophage (MΦ) depletion on levels of CD206+ regulatory macrophages.

Fig. 6

(A) Total number of CD206+ macrophages in lining and stroma of fractured limbs for carrier control and experimental macrophage depleted MaFIA treatment groups. With depletion on Day −2 and Day 2, experimental treatment limbs showed a decrease in CD206+ macrophages in the stroma compared to carrier control, but the differences were not statistically significant (#P < 0.09). (B) Total number of CD206+ macrophages in lining and stroma of fractured limbs for carrier control and experimental macrophage depleted clodronate treatment groups. (C) Medial femur of histological sections stained with an antibody against the CD206 surface marker of activated macrophages from the control and experimental treatment groups for MaFIA and clodronate mice receiving local injection 2 days after fracture (Day 2). Scale bar is 50 mm; brown = positive IHC stain, blue = hematoxylin counterstain.