TABLE 5.
logP values and ratios of zones of inhibition with pertinent inhibitors for RW2802 (PDR5) and JG436 (pdr5)
| Compound | ClogP | MlogPa | Zone of inhibition (cm)b for:
|
Ratio of zone for JG436 to zone for RW2802 | |
|---|---|---|---|---|---|
| RW2802 | JG436 | ||||
| Tri-n-alkyltin | |||||
| Trimethyltin chloride | −0.512 | −0.292 | 1.0 ± 0.1 | ||
| Triethyltin chloride | 1.075 | 0.568 | 1.3 ± 0.1 | ||
| Tripropyltin chloride | 2.662 | 2.716 | 1.6 ± 0.1 | ||
| Tributyltin chloride | 4.249 | 3.11 | 1.4 ± 0.1 | ||
| Tripentyltin chloride | 5.836 | 1.2 ± 0.1 | |||
| Other inhibitors | |||||
| Cycloheximide | −0.49 | 2.1 ± 0.1 | 3.0 ± 0.1 | 1.4 ± 0.1 | |
| Lincomycin | −0.12 | 1.7 ± 0.1 | 2.9 ± 0.1 | 1.7 ± 0.1 | |
| Chloramphenicol | 0.69 | 2.1 ± 0.1 | 4.3 ± 0.2 | 2.0 ± 0.1 | |
| Triphenyltin chloride | 3.56 | 2.2 ± 0.1 | 2.6 ± 0.1 | 1.2 ± 0.1 | |
| Clotrimazole | 5.05 | 2.2 ± 0.1 | 3.4 ± 0.2 | 1.6 ± 0.1 | |
a
Measured logP. See reference 16.
b
Concentrations of inhibitors in assays were as follows: triphenyltin chloride, 0.08 mmol; cycloheximide, 0.035 mmol; chloramphenicol, 0.123 mmol; lincomycin, 0.148 mmol; and clotrimazole, 0.015 mmol. Values for lincomycin are from an experiment described in reference 13.