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Mechanism of MiRNA/LncRNA interaction. The interaction mechanism between miRNAs and lncRNAs is as follows: (1) The two directly interact with each other. (2) lncRNAs inhibit miRNAs by competitively binding the 3 ‘-UTR of miRNA target mRNA. (3) lncRNAs, as ceRNA, inhibit the expression of miRNA by using the “miRNA sponge”. MiRNAs may regulate lncRNA expression through the similar mechanism by which miRNAs regulate mRNA, since LncRNA structure is similar to that of mRNA.
