Table 3.
Tumor derived exosome miRNA on tumor MDSCs.
MiRNAs | Target genes/signal pathways | Function on MDSCs | Tumor | Ref. |
---|---|---|---|---|
miR-29a miR-92a | PDCD4/STAT3 | To improve differentiation | Glioma | (75) |
miR-10a/miR-21 | Dicer1/PTEN | To enhance the expansion/activation | Glioma | (77) |
miR-21a | SOCS3/PIAS3/JAK/STAT | To exaggerate the proliferation/immunosuppressive functions | LLC | (76) |
miR-9/miR-181a | RORA/PTEN | To promote the proliferation and activity | Breast cancer | (76) |
miR-107 | To induce the proliferation/activation | Gastric cancer | (78) | |
miR-let-7i | IL-6/IL-17/IL-1b | To restrain the roles | Pancreatic cancer | (74) |