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. 2022 Mar 14;12:772351. doi: 10.3389/fonc.2022.772351

Table 3.

Tumor derived exosome miRNA on tumor MDSCs.

MiRNAs Target genes/signal pathways Function on MDSCs Tumor Ref.
miR-29a miR-92a PDCD4/STAT3 To improve differentiation Glioma (75)
miR-10a/miR-21 Dicer1/PTEN To enhance the expansion/activation Glioma (77)
miR-21a SOCS3/PIAS3/JAK/STAT To exaggerate the proliferation/immunosuppressive functions LLC (76)
miR-9/miR-181a RORA/PTEN To promote the proliferation and activity Breast cancer (76)
miR-107 To induce the proliferation/activation Gastric cancer (78)
miR-let-7i IL-6/IL-17/IL-1b To restrain the roles Pancreatic cancer (74)