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. 2022 Mar 14;16:835645. doi: 10.3389/fnins.2022.835645

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Copyright © 2022 Gabriele, Abel, Fox, Wray and Arber.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Domains of amyloid precursor protein (APP) and the APP-like proteins (APLP) protein family members. APP and its mammalian homologues APLP1 and APLP2 share similar domain architecture including the E1 and E2-domains, which potentially drive dimerisation. APP770, APP751, and APLP2 are characterised by the Kunitz type protease inhibitor domain (KPI) upstream of E2. APP770 includes also the OX2 domain. Both APP and APLPs contain a transmembrane domain (TMD) but only APPs have the Aβ sequence (purple). Created with BioRender.com.