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. 2022 Mar 14;10:819044. doi: 10.3389/fcell.2022.819044

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Copyright © 2022 Chang, Yi, Wang, Cao, Zhou, Ge, Muhammad, Zhang, Feng, Yan, Felici, Shen and Cao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Methylation and demethylation of m⁶A on RNA. The N ⁶-methyladenosine (m⁶A) modification is imposed by a heterocomplex of two methyltransferases METTL3-METTL14 termed “writers”, assisted by WTAP. ALKBH5 and FTO, termed “erasers” catalyzes the direct removal of m⁶A. YTH family proteins termed “readers” recognize the m⁶A to carry out subsequent functions.