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. 2022 Mar 14;10:819044. doi: 10.3389/fcell.2022.819044

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Copyright © 2022 Chang, Yi, Wang, Cao, Zhou, Ge, Muhammad, Zhang, Feng, Yan, Felici, Shen and Cao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The function of YTHDC1, YTHDC2 and YTHDF2 in sperm cells. (A) YTHDC2 binds multiple transcripts including Ccna2 and other mitotic transcripts and interacts with RNA granule components, suggesting that proper progression of germ cells through meiosis is licensed by YTHDC2 through post-transcriptional regulation; when YTHDC2 is inactivated, spermatocytes do not pass the zygotene stage. (B) YTHDC1 can recruit SRSF3 and block SRSF10 to regulate alternative splicing of pre-mRNA crucial for maintaining spermatogonia. In addition, YTHDC1 can also promote the output of m⁶A-containing mRNA. YTHDF2 binds to the m⁶A site and degrade RNAs containing m⁶A involved in controlling migration and proliferation of spermatogonia.