Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Mar 14;10:819044. doi: 10.3389/fcell.2022.819044

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2022 Chang, Yi, Wang, Cao, Zhou, Ge, Muhammad, Zhang, Feng, Yan, Felici, Shen and Cao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

The main role of m⁶A in the stage of embryonic development. The level of m6A modification increased slowly in mouse 2-cell, 4-cell and 8-cell embryos but suddenly increased significantly in the transition period from morula to blastocyst which is due to the METTL3 and METTL14 active transcription of many pluripotency genes (includes Nanog, Oct4, Sox2 and so on). In the MZT, METTL3 mediates the m6A modification on pre-mRNA to degrade maternal mRNA and YTHDF2 can promote the process, which is reprogramming zygotic mRNA for zygotic development.